METABOLISM OF GLUTATHIONE
نویسندگان
چکیده
منابع مشابه
Inborn errors in the metabolism of glutathione
Glutathione is a tripeptide composed of glutamate, cysteine and glycine. Glutathione is present in millimolar concentrations in most mammalian cells and it is involved in several fundamental biological functions, including free radical scavenging, detoxification of xenobiotics and carcinogens, redox reactions, biosynthesis of DNA, proteins and leukotrienes, as well as neurotransmission/neuromod...
متن کاملMetabolism and function of glutathione: an overview.
Many functions have been ascribed to glutathione, a tripeptide that has been known for almost a century.* Glutathione is found in virtually all mammalian cells, usually in substantial concentrations (0.510 mM). The concentration of glutathione in extracellular fluids such as blood plasma is in the micromolar range. The intracellular concentration of glutathione exceeds by far that of glutathion...
متن کاملRole of pyridoxine in glutathione metabolism.
Richter, D. & Dawson, R. M. C. (1948b). Amer. J. Phy8iol. 154, 73. Roberts, E. & Frankel, S. (1950). J. biol. Chem. 187, 55. Schwerin, P., Bessman, S. P. & Waelsch, H. (1950). J. biol. Chem. 184, 37. Soep, H. & Janssen, P. A. J. (1961). Biochem. Pharmacol. 7, 81. Sporn, M. B., Dingman, W., Defalco, A. & Davies, R. K. (1959). J. Neurochem. 5, 62. Tigane, E., Wade, E. H. M., Wong, J. T.-F. & Hane...
متن کاملEmerging regulatory paradigms in glutathione metabolism.
One of the hallmarks of cancer is the ability to generate and withstand unusual levels of oxidative stress. In part, this property of tumor cells is conferred by elevation of the cellular redox buffer glutathione. Though enzymes of the glutathione synthesis and salvage pathways have been characterized for several decades, we still lack a comprehensive understanding of their independent and coor...
متن کاملGlutathione metabolism and its implications for health.
Glutathione (gamma-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight thiol, and GSH/glutathione disulfide is the major redox couple in animal cells. The synthesis of GSH from glutamate, cysteine, and glycine is catalyzed sequentially by two cytosolic enzymes, gamma-glutamylcysteine synthetase and GSH synthetase. Compelling evidence shows that GSH synthesis is regulated ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1951
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)77716-3